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The downloadable demo of Resident Evil 5 exceeded 4 million downloads worldwide during its release on the PlayStation Store and Xbox Live services, with over 1.8 million of these downloads taking place in the first three days.
Official Xbox Magazine gave Resident Evil 5 a 9 out of 10, praising its combat. Sheva's artificial intelligence was praised, though criticized for its inability to be strategized with. The fact that enemies come at all speeds was received well. Of note were gun-wielding enemies which can fire blindly and duck for cover. The game's control scheme was criticized for not allowing the player to shoot and move at the same time. The new inventory system was also called into question, the review stating that many will not like it, though it is "essentially game balancing". Resident Evil 5 was summarized as "an action spectacular with terrific production values" and as an "excellent co-op game.
PlayStation Official Magazine gave the game an 8 out of 10, also praising Sheva’s AI, but also criticizing the inventory management and the cover system that "all but kills the fun.